I am also a contractor (usually have a bed full of building materials and/or tools), tow a 5th wheel when I get a chance to get out of town and I sometimes double-tow a bass boat behind the 5th wheel.
I've never been interested in "racing" my truck, just love having extra power available when I need it and hopefully an extra MPG or two.
I run the Spartan
Tuned DashDaq, DPF delete system with a short Magna-Flow muffler, a "Green" Air filter and for towing, I added the RoadMaster active suspension load levelers.
I've experimented with various "tunes" and my choice for everyday driving and towing is the 250. It gives me the best fuel economy and tows my trailer/boat with lots of reserve power and without any heat issues, so I didn't have the need for the down-pipe. I still still remember the look of a couple of guys faces that I passed in New Mexico. I had been following them for about 15 miles on some very winding roads. They were driving 30 mph (60 mph speed limit). We finally got a short stretch of straight road so I put the pedal to the metal and passed them in a flash, running 80 mpg with my 5th wheel and boat! Never saw exhaust temperature go above 1200.
Adding the "Green" filter didn't seem to change things much over the stock filter, but it is reusable.
I've towed slide-in truck campers and 5th wheels for years and always used air bags. I carried a small air compressor (I could have installed an on-board compressor) because the airbags would leak-down a little and would require adjustment due to changes in load (fuel tank level, changes in how the 5th wheel was loaded, water/waste water levels in camper, etc.). Decided to try the Roadmasters on my 2010 F250 Crew Cab 4x4 and they do the trick, because they are self adjusting. Also, since they are an active-suspension component, they help my truck handle much, much better than the airbags, which tend to feel "rubbery", particularly in mountain driving.
The only thing that I wish I had was more fuel capacity. After doing the "research", I'm going to go with the Titan due to the construction and weight.