Join Date: Sep 2005
Thanked 143 Times in 37 Posts
I think you'll find the issue to be more with when you are comfortable with tuning the truck.
As far as break-in, tuning will not cause any positive or negative effects assuming the truck isn't just outright abused with the tune in place.
However, just like the failure rates on electronics- the higher percentage of bad parts will rear their head when the truck is brand new. Once you have enough miles on the truck for you to be comfortable that you are driving a solid unit, that is the time to tune.
Taking the DPF on and off to get window motors, door locks, or interior stuff fixed can be a real PITA- but other than that, any time is the right time.