There are no worries about taking a box off. You can kill off an injection pump or transmission with a programmer, box, or stock. The best way to assure you do not hurt the truck is to make a plan for where you want to go as far as power and mods before spending any money. Then, start from the ground up, building a stout foundation for the power you are going to pour on later. This will keep you from breaking, and spending the money twice.
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